This supplement reverses the hallmarks of old age and promotes healthier aging

Research has shown that supplementing older adults with GlyNAC – a combination of glycine and N-acetylcysteine ​​– wards off several key indicators of aging and keeps people healthier as they age. Not only that, but older people also appeared to be fitter, stronger and with a slimmer waist after taking it GlyNAC supplement.

As reported in the study, scientists at Baylor College of Medicine studied the effect of GlyNAC supplementation on 24 older adults and 12 younger people in a randomized, double-blind human clinical trial.

After 16 weeks, GlyNAC supplementation was found to be associated with a wide range of benefits on key markers of aging and age-related defects. This included oxidative stress, glutathione deficiency, mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular aging. Meanwhile, no improvements were seen in those given a placebo.

In turn, older people who received doses of GlyNAC had stronger muscles, lower blood pressure and smaller waist sizes. They were able to train harder and their walking speed improved, which is a surprisingly good indicator of poor health in old age.

The researchers explain that the key to GlyNAC’s benefits lies in its ability to restore mitochondrial health and correct oxidative stress.

Mitochondria – the “powerhouse of the cell” as textbooks like to say – generate most of the energy needed to fuel the cell’s biochemical reactions. However, as we age, they become less efficient at producing energy. Just as their previous mouse studies have suggested, this clinical trial showed that GlyNAC supplementation appeared to increase mitochondrial function in older people to levels found in young people.

In terms of oxidative stress, this describes the process by which the body sustains damage from high levels of toxic waste products known as reactive oxygen species or free radicals, resulting in cell breakdown and DNA damage. Our bodies produce a natural antioxidant – glutathione – to counteract this, but levels of this also decrease as we age. The latest research showed that supplementation with GlyNAC helps correct this glutathione deficiency and reduces oxidative stress in older people.

The GlyNAC supplementation also appeared to have a real impact on the health and well-being of the participants. Older people who received GlyNAC experienced improvements in muscle strength and greater exercise capacity, as well as significant improvement in walking speed, which is known to be associated with increased survival rates in the elderly.

“One of the intriguing questions from this study is why there are so many improvements toward health promotion. We believe this is due to the combined efforts of three separate components – glycine, cysteine ​​(from NAC) and glutathione, and not just glutathione itself. Glycine and cysteine ​​themselves are both very important for cellular health, and GlyNAC delivers both,” explains Dr. Rajagopal Sekhar, corresponding author of the study and professor of medicine at Baylor, said in a statement.

“Glycine and cysteine ​​are building blocks for the formation of glutathione, which also has health benefits. We believe that the improvements in this study and in our previous studies are the result of the combined effects of glycine and NAC and glutathione, and we call this combination the “Power of 3,” he added.

Despite how important the aging process is to everyone, scientists still know surprisingly little about how it unfolds. Through clinical trials like this, we can help unravel some of its mysteries and find ways to ensure the world’s growing older population lives happier, healthier lives.

“It is believed that correcting aging traits could help people age in a healthier way,” Sekhar added. “However, we do not fully understand why these hallmarks of aging occur in the first place, and therefore there are no proven solutions through randomized clinical trials in humans to improve or correct aging hallmarks in aging people.”

The study was published in the Journals of Gerontology Series A.

The content of this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of qualified healthcare providers with any questions you may have regarding medical conditions.

An earlier version of this article appeared in August 2022.

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